Evidence from randomized controlled clinical trials is widely regarded as the most reliable basis for evaluating the efficacy of new medical treatments. Statistical methods play a crucial role in the entire lifecycle of these trials, encompassing justification, design, and analysis.
This second edition of Introduction to Randomized Controlled Clinical Trials delivers a concise yet comprehensive overview of the principles that underpin this important field. Within its pages, you will find:
- A detailed exploration of the concepts behind randomization.
- Methods for effectively designing and analyzing clinical trials.
- Insights into meta-analysis and specialized trial designs, including cross-over trials, cluster-randomized designs, and equivalence studies.
- A new chapter dedicated to binary outcomes and survival analysis.
- Numerous real-world examples drawn from medical literature to enhance understanding.
- Exercises at the end of each chapter to reinforce learning, along with solutions provided in an appendix.
This latest edition also features updated references and revised examples to ensure contemporary relevance. The author utilizes Minitab and R software throughout the text, making it easier for readers to implement the presented methods.
Authors:
John N.S. N.S. Matthews (Author)
Edition:
2nd
Publication Date:
June 26, 2006
From the book:
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